Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(Myh6-Tnnt2*R92L)1Jcf
Name:	transgene insertion 1, Jil C Tardiff
MGI ID:	MGI:3693255
Synonyms:	R92L
Transgene:	Tg(Myh6-Tnnt2*R92L)1Jcf  Location: unknown
Alliance:	Tg(Myh6-Tnnt2*R92L)1Jcf page

Strain of Origin:

Not Specified

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Myh6-Tnnt2*R92L)1Jcf expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Tnnt2 (MGI:104597) Transgene codes for a protein with an arginine to leucine mutation.   Mutation details: This transgene expresses a mouse Tnnt2 gene, with codon 92 mutated to encode a leucine instead of the arginine and an 11-amino acid c-myc epitope added to the 5' end of the coding region, under the control of a rat alpha-myosin heavy chain promoter. This line expresses 50% of the total Tnnt2 as the mutant transgenic form. (J:104369)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:104369 Ertz-Berger BR, et al., Changes in the chemical and dynamic properties of cardiac troponin T cause discrete cardiomyopathies in transgenic mice. Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18219-24
All:	9 reference(s)