Tg(CALCA-RET*C634R)3Bajp
Transgene Detail
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| Symbol: |
Tg(CALCA-RET*C634R)3Bajp |
| Name: |
transgene insertion 3, Bruce AJ Ponder |
| MGI ID: |
MGI:3525092 |
| Synonyms: |
2A-3, CT-2A-3, RET C634R |
| Transgene: |
Tg(CALCA-RET*C634R)3Bajp Location: unknown
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| Alliance: |
Tg(CALCA-RET*C634R)3Bajp page
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| Strain of Origin: |
CBA x C57BL/6
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Mutation details: A mutant human RET cDNA containing a cysteine to arginine mutation at codon 634 was flanked by the human calcitonin promoter and SV40 polyA sequences. A single copy of the transgene was incorporated in the genome. Transgene expression was strong in the pancreas and thyroid and weak in the lung. No expression was detected in the adrenal gland or kidney.
(J:70566)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:70566 Reynolds L, et al., C-cell and thyroid epithelial tumours and altered follicular development in transgenic mice expressing the long isoform of MEN 2A RET. Oncogene. 2001 Jul 5;20(30):3986-94 |
| All: |
4 reference(s) |
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Analysis Tools
