Slc25a19tm1Mjl
Targeted Allele Detail
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| Symbol: |
Slc25a19tm1Mjl |
| Name: |
solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19; targeted mutation 1, Marjorie J Lindhurst |
| MGI ID: |
MGI:3691853 |
| Synonyms: |
Slc25a19- |
| Gene: |
Slc25a19 Location: Chr11:115505004-115519121 bp, - strand Genetic Position: Chr11, 80.91 cM, cytoband E2
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| Alliance: |
Slc25a19tm1Mjl page
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Examples of Slc25a19tm1Mjl/+ control and Slc25a19tm1Mjl/Slc25a19tm1Mjl embryos at E10.5
Show the 2 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:115337
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| Parent Cell Line: |
TC1/TC-1 (ES Cell)
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| Strain of Origin: |
129S6/SvEvTac
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutation: |
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Disruption caused by insertion of vector
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Mutation details: Exons 4-6 were replaced with a neomycin resistance cassette, causing the deletion of amino acids 97-258 and rendering the protein nonfunctional.
(J:115337)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Slc25a19 Mutation: |
40 strains or lines available
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| Original: |
J:115337 Lindhurst MJ, et al., Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia. Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15927-32 |
| All: |
1 reference(s) |
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Analysis Tools
