Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Tg(Sp7-tTA,tetO-EGFP/cre)1Amc
Name:	transgene insertion 1, Andrew P McMahon
MGI ID:	MGI:3689350
Synonyms:	osterix-Cre, Osx1-cre, Osx1-Cre, Osx1-GFP::Cre, Osx-Cre, Osx-Cre::GFP, Osx-gfp, The Sp7-Cre-EGFP
Transgene:	Tg(Sp7-tTA,tetO-EGFP/cre)1Amc  Location: unknown
Alliance:	Tg(Sp7-tTA,tetO-EGFP/cre)1Amc page

Strain of Origin:

CD-1

Transgene Type:    Transgenic (Inducible, Recombinase, Reporter, Transactivator) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Tg(Sp7-tTA,tetO-EGFP/cre)1Amc expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Sp7 (MGI:2153568)   Mutation details: A tTA-regulated GFP::Cre construct, which has the tetracycline-regulated transactivator (tTA) cassette upstream of a tetracycline-responsive element (tetO)-controlled Enhanced Green Fluorescent Protein/cre fusion protein was used to modify a bacterial artificial chromosome (BAC) encoding exon 1 of the mouse Sp7 gene (formerly osterix or Osx1). An frt-flanked selection cassette following the tTA-regulated GFP::Cre was removed from correctly targeted bacteria via transient flpe expression. A 5.2 kb portion of the modified BAC (Osx1-GFP::Cre) was used for pronuclear injection into fertilized CD1 embryos. (J:114494)

Activity:	Tissue activity of this recombinase allele
Driver:	Sp7 (mouse) Summary of all recombinase alleles driven by Sp7. Comparative matrix view of recombinase activities Alliance mouse Sp7 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	20 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

List all tumor models in MMHCdb carrying Tg(Sp7-tTA,tetO-EGFP/cre)1Amc

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available

Original:	J:114494 Rodda SJ, et al., Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors. Development. 2006 Aug;133(16):3231-44
All:	292 reference(s)