Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(CD46)2Gsv
Name:	transgene insertion 2, Frank Grosveld
MGI ID:	MGI:3688752
Synonyms:	MCP YAC, MCP-YAC line 2, MY II, Tg(CD46)2Olds, Tg(MCP)Olds2, YAC-CD46, YAC CD46 line 2
Transgene:	Tg(CD46)2Gsv  Location: unknown  Genetic Position: Chr9, Syntenic
Alliance:	Tg(CD46)2Gsv page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(CD46)2Gsv expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human CD46 (4179) Cd46  (MGI:1203290)   Mutation details: The transgene comprises a partially intact, approximately 420-kb yeast artificial chromosome (YAC) from the Imperial Cancer Research Fund (ICRF, London, UK), designatied AM2: 6C10, that contains the complete human CD46/MCP gene including its 5' and 3' flanking regions. The genome of transgenic mice of line MY II contains 10-12 intact copies of CD46. The expected 4.5 - 4.8-kb transcript, as well as several smaller RNAs, are expressed at high levels in all tissues examined from transgenic mice. Immunohistochemistry likewise detects patterns of expression of human CD46 protein in transgenic mouse tissues similar to those in human tissues. FACS analysis detects CD46 on transgenic spleen cells at approximately 10-fold higher levels than on human splenocytes. (J:113644)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:113644 Yannoutsos N, et al., A membrane cofactor protein transgenic mouse model for the study of discordant xenograft rejection. Genes Cells. 1996 Apr;1(4):409-19
All:	12 reference(s)