Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Spi1tm2Dgt
Name:	Spi-1 proto-oncogene; targeted mutation 2, Daniel G Tenen
MGI ID:	MGI:3688438
Synonyms:	PU.1F
Gene:	Spi1  Location: Chr2:90912750-90946104 bp, + strand  Genetic Position: Chr2, 50.44 cM, cytoband E3
Alliance:	Spi1tm2Dgt page

Germline Transmission:	Earliest citation of germline transmission: J:114150
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: LoxP sites were inserted in intron 3 and a loxP-flanked neomycin selection cassette was inserted into intron 5. (J:114150)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Spi1 Mutation:	27 strains or lines available

Original:	J:114150 Iwasaki H, et al., Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation. Blood. 2005 Sep 1;106(5):1590-600
All:	19 reference(s)