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Apctm2Rak
Targeted Allele Detail
Summary
Symbol: Apctm2Rak
Name: APC, WNT signaling pathway regulator; targeted mutation 2, Raju Kucherlapati
MGI ID: MGI:3688435
Synonyms: Apc580S, ApcCKO, Apcloxp
Gene: Apc  Location: Chr18:34353977-34455605 bp, + strand  Genetic Position: Chr18, 18.53 cM
Alliance: Apctm2Rak page
Stunted growth, short whiskers, sparse hair coat and abnormal tooth development in the Apctm2Rak/Apctm2Rak Tg(KRT14-cre)8Brn/0 mouse

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:114152
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP sites were inserted through homologous recombination to flank exon 14. An adjacently inserted frt-flanked neomycin selection cassette was removed through Flp-mediated recombination, leaving a single frt site in intron 14. (J:114152)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 24 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Apctm2Rak
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apc Mutation:  154 strains or lines available
References
Original:  J:114152 Kuraguchi M, et al., Adenomatous Polyposis Coli (APC) is required for normal development of skin and thymus. PLoS Genet. 2006;2(9):e146
All:  51 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory