Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pycardtm1Flv
Name:	PYD and CARD domain containing; targeted mutation 1, Richard A Flavell
MGI ID:	MGI:3686870
Synonyms:	Asc-, Pycard-
Gene:	Pycard  Location: Chr7:127590545-127593039 bp, - strand  Genetic Position: Chr7, 69.88 cM, cytoband F4
Alliance:	Pycardtm1Flv page

Germline Transmission:	Earliest citation of germline transmission: J:113333
Parent Cell Line:	Lex-1 (ES Cell)
Strain of Origin:	129S5/SvEvBrd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2, 3 and part of exon 1, including the ATG, were replaced with an IRES-LacZ-MC1-neo cassette. RT-PCR confirmed absence of transcript in mutant splenocytes. (J:113333)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pycard Mutation:	13 strains or lines available

Original:	J:113333 Sutterwala FS, et al., Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity. 2006 Mar;24(3):317-27
All:	92 reference(s)