Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gzmmtm1(cre)Mjs
Name:	granzyme M (lymphocyte met-ase 1); targeted mutation 1, Mark J Smyth
MGI ID:	MGI:3665444
Synonyms:	GrzM-, GrzM cre
Gene:	Gzmm  Location: Chr10:79524854-79531095 bp, + strand  Genetic Position: Chr10, 39.72 cM, cytoband C
Alliance:	Gzmmtm1(cre)Mjs page

Germline Transmission:	Earliest citation of germline transmission: J:113213
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Gzmmtm1(cre)Mjs expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Gzmm (MGI:99549)   Mutation details: Cre recombinase cDNA was inserted directly upstream of the ATG in exon 1. An frt-flanked neo was included in the vector and was removed in vivo. RT-PCR demonstrated expression of cre in the mutant mice and the absence of full-length Gzmm transcript in mutants. (J:113213)

Activity:	Tissue activity of this recombinase allele
Driver:	Gzmm (mouse) Summary of all recombinase alleles driven by Gzmm. Alliance mouse Gzmm gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gzmm Mutation:	7 strains or lines available

Original:	J:113213 Pao LI, et al., Functional analysis of granzyme M and its role in immunity to infection. J Immunol. 2005 Sep 1;175(5):3235-43
All:	5 reference(s)