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Acta2tm1Rjs
Targeted Allele Detail
Summary
Symbol: Acta2tm1Rjs
Name: actin alpha 2, smooth muscle, aorta; targeted mutation 1, Robert J Schwartz
MGI ID: MGI:3665248
Gene: Acta2  Location: Chr19:34218490-34232990 bp, - strand  Genetic Position: Chr19, 29.41 cM, cytoband C3
Alliance: Acta2tm1Rjs page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:113261
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA pol2neobpA cassette was inserted into the locus between the promoter and the coding region to disrupt transcription. Northern blots confirmed absence of transcript in mutant aorta, intestine and uterus. Western blot confirm absence of protein in mutant aorta, intestine and uterus. (J:113261)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acta2 Mutation:  54 strains or lines available
References
Original:  J:113261 Schildmeyer LA, et al., Impaired vascular contractility and blood pressure homeostasis in the smooth muscle alpha-actin null mouse. FASEB J. 2000 Nov;14(14):2213-20
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory