Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gipc1tm1Mvc
Name:	GIPC PDZ domain containing family, member 1; targeted mutation 1, Moses V Chao
MGI ID:	MGI:3663921
Synonyms:	Gipc1-, synectin-null
Gene:	Gipc1  Location: Chr8:84379306-84391323 bp, + strand  Genetic Position: Chr8, 40.22 cM, cytoband C3
Alliance:	Gipc1tm1Mvc page

Germline Transmission:	Earliest citation of germline transmission: J:111724
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to replace exons 2-4, which encode the entire N-terminal, PDZ and a part of the C-terminal domain, with a neomycin resistance gene. Expression was not detected by Western blot of mutant brain lysates. (J:111724)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gipc1 Mutation:	40 strains or lines available

Original:	J:111724 Yano H, et al., BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Nat Neurosci. 2006 Aug;9(8):1009-18
All:	2 reference(s)