Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bst1tm1Thir
Name:	bone marrow stromal cell antigen 1; targeted mutation 1, Toshio Hirano
MGI ID:	MGI:3663800
Synonyms:	BST-1-
Gene:	Bst1  Location: Chr5:43976235-44000810 bp, + strand  Genetic Position: Chr5, 23.84 cM
Alliance:	Bst1tm1Thir page

Germline Transmission:	Earliest citation of germline transmission: J:111424
Parent Cell Line:	E14.1TG3B1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A vector was designed to replace sequence encoding part of exon 1, all of exon 2 and part of exon 3 with a neomycin resistnce cassette in opposite transcriptional orientation. RT-PCR confirmed absence of transcript in mutant bone marrow, spleen and thymus. (J:111424)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bst1 Mutation:	26 strains or lines available

Original:	J:111424 Itoh M, et al., Deletion of bone marrow stromal cell antigen-1 (CD157) gene impaired systemic thymus independent-2 antigen-induced IgG3 and mucosal TD antigen-elicited IgA responses. J Immunol. 1998 Oct 15;161(8):3974-83
All:	12 reference(s)