Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Atg5tm1Myok Name: autophagy related 5; targeted mutation 1, Minesuke Yokoyama MGI ID: MGI:3663625 Synonyms: atg5f, Atg5flox Gene: Atg5  Location: Chr10:44144354-44240287 bp, + strand  Genetic Position: Chr10, 23.24 cM Alliance: Atg5tm1Myok page

Cataract development in Atg5tm1Myok/Atg5tm1Myok Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Tg(Cryaa-cre)10Mlr/0 mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:110050
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A targeting vector was designed to flank exon 3 with loxP sites. A neomycin resistance cassette was included such that expression of cre recombinase would remove both exon 3 and the neo. (J:110050)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	20 anatomical structure(s)

List all tumor models in MMHCdb carrying Atg5tm1Myok

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Atg5 Mutation:	27 strains or lines available

Original:	J:110050 Hara T, et al., Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature. 2006 Jun 15;441(7095):885-9
All:	270 reference(s)