Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Nkx2-5tm4Rph
Name:	NK2 homeobox 5; targeted mutation 4, Richard P Harvey
MGI ID:	MGI:3655239
Synonyms:	Nkx2-5-, Nkx2-5GFP, Nkx2,5GFP
Gene:	Nkx2-5  Location: Chr17:27057638-27063962 bp, - strand  Genetic Position: Chr17, 13.6 cM
Alliance:	Nkx2-5tm4Rph page

Germline Transmission:	Earliest citation of germline transmission: J:81343
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: Sequence encoding enhanced GFP was inserted at codon 35 of the endogenous locus via homologous recombination. (J:81343)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	49 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nkx2-5 Mutation:	21 strains or lines available

Original:	J:81343 Biben C, et al., Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5. Circ Res. 2000 Nov 10;87(10):888-95
All:	16 reference(s)