Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Ttntm1.1Her Name: titin; targeted mutation 1.1, Joachim Herz MGI ID: MGI:3654306 Gene: Ttn  Location: Chr2:76534324-76812891 bp, - strand  Genetic Position: Chr2, 45.13 cM, cytoband D Alliance: Ttntm1.1Her page

Ttntm1.1Her/Ttntm1.1Her embryos fail to thrive after E9 Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:111284
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exons 358 (MEx1) and 359 (MEx2) were removed by Cre mediated recombination. In situ hybridization analysis confirms the expression of a truncated protein lacking the kinase domain in homozygous embryos. (J:81993, J:111284)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ttn Mutation:	1455 strains or lines available

Original:	J:111284 Weinert S, et al., M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere. J Cell Biol. 2006 May 22;173(4):559-70
All:	3 reference(s)