Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Msh6tm1Wed
Name:	mutS homolog 6; targeted mutation 1, Winfried Edelmann
MGI ID:	MGI:3653701
Synonyms:	Msh6TD
Gene:	Msh6  Location: Chr17:88282490-88298320 bp, + strand  Genetic Position: Chr17, 57.87 cM
Alliance:	Msh6tm1Wed page

Germline Transmission:	Earliest citation of germline transmission: J:92555
Parent Cell Line:	WW6 (ES Cell)
Strain of Origin:	STOCK 129/Sv and C57BL/6J and SJL

Allele Type:    Targeted (Modified isoform(s)) Mutation:    Nucleotide substitutions   Mutation details: A targeting vector was designed to insert a T1217D mutation in exon 8. RT-PCR and Western blot analysis showed that the mutation did not interfere with normal gene expression or the stability of the mutant protein. (J:92555)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Msh6 Mutation:	52 strains or lines available

Original:	J:92555 Yang G, et al., Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility. Cancer Cell. 2004 Aug;6(2):139-50
All:	3 reference(s)