Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(tetO-CDK5R1/GFP)337Lht
Name:	transgene insertion 337, Li-Huei Tsai
MGI ID:	MGI:3653679
Synonyms:	CK-p25 Tg, p25(337), p25-CK, p25-GFP, tetO-p25-GFP, Tg(tetO-p25/GFP)33Lth
Transgene:	Tg(tetO-CDK5R1/GFP)337Lht  Location: unknown
Alliance:	Tg(tetO-CDK5R1/GFP)337Lht page

Strain of Origin:

C57BL/6J

Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence, Reporter) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Tg(tetO-CDK5R1/GFP)337Lht expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human CDK5R1 (8851) Cdk5r1  (MGI:101764)   Mutation details: The transgene expresses the carboxy-terminal proteolytic fragment (p25) of human cyclin-dependent kinase 5, regulatory subunit 1, bearing a carboxy-terminal green fluorescent protein (GFP) tag, under control of the tetracycline operator. The purpose of the GFP tag is to differentiate immunologically the transgene-encoded p25 from the endogenous p35 protein. (J:104240)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:104240 Cruz JC, et al., Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron. 2003 Oct 30;40(3):471-83
All:	27 reference(s)