Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ly86tm1Kmiy
Name:	lymphocyte antigen 86; targeted mutation 1, Kensuke Miyake
MGI ID:	MGI:3641422
Synonyms:	MD-1-
Gene:	Ly86  Location: Chr13:37529276-37603012 bp, + strand  Genetic Position: Chr13, 14.7 cM
Alliance:	Ly86tm1Kmiy page

Germline Transmission:	Earliest citation of germline transmission: J:109720
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting construct was designed to replace exon 1 with a neomycin resistance gene. Exon 1 encodes the signal sequence and 27 amino acids of the expressed protein. Flow cytometry of spleen cells did not detect protein from mutant cells. (J:109720)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ly86 Mutation:	17 strains or lines available

Original:	J:109720 Nagai Y, et al., Requirement for MD-1 in cell surface expression of RP105/CD180 and B-cell responsiveness to lipopolysaccharide. Blood. 2002 Mar 1;99(5):1699-705
All:	11 reference(s)