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Gene Expression Data
Assay Details
Assay
Reference: J:109566 Petit N, et al., Patterns of expression of the three cerebral cavernous malformation (CCM) genes during embryonic and postnatal brain development. Gene Expr Patterns. 2006 Jun;6(5):495-503
Assay type: RNA in situ
MGI Accession ID: MGI:3639606
Gene symbol: Ccm2
Gene name: cerebral cavernous malformation 2
Probe: Ccm2/Mgc4607
Probe preparation: Antisense labelled with S35 RNA
Assay notes: Fixative was 4% formalin.
Results
Specimen 1C: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: central nervous system Strong Graded 1C Expression is strongest in the posterior neural tube.
Specimen 1G: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: cerebral cortex intermediate zone Strong 1G
TS22: cerebral cortex ventricular layer Strong 1G
TS22: cortical plate Strong 1G
TS22: ganglionic eminence Strong 1G
Specimen 1K: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: basal columns Very strong 1K
TS22: alar columns Moderate 1K
TS22: dorsal root ganglion Present 1K
Specimen Not Shown: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: medulla oblongata Present
TS22: midbrain roof plate Present
TS22: thalamus Present
TS22: brain vascular element Absent Absent in the brain vasculature.
Specimen 1O: postnatal day 8 (more )
Structure Level Pattern Image Note
TS28: brain Strong 1O Expression is in all neuronal layers throughout the brain.
TS28: cerebellum white matter Present 1O
TS28: corpus callosum Present 1O
TS28: hippocampus Present 1O
Specimen 1S: postnatal day 19 (more )
Structure Level Pattern Image Note
TS28: brain Strong 1S Expression is in all neuronal layers throughout the brain.
TS28: cerebellum Purkinje cell layer Very strong 1S
TS28: cerebellum external granule cell layer Weak 1S
TS28: cerebellum internal granule cell layer Weak 1S
TS28: cerebellum white matter Weak 1S
TS28: corpus callosum Weak 1S
Specimen 1W: postnatal day 19 (more )
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Strong 1W
TS28: retina inner nuclear layer Strong 1W
TS28: retina outer nuclear layer Strong 1W
Specimen 1YY: postnatal adult (more )
Structure Level Pattern Image Note
TS28: brain Strong 1YY Expression is in all neuronal layers throughout the brain.
TS28: cortical layer II Present 1YY
TS28: cortical layer III Present 1YY
TS28: cortical layer IV Present 1YY
TS28: cortical layer V Present 1YY
TS28: cortical layer VI Present 1YY
TS28: cortical layer I Absent 1YY
Specimen Not Shown: postnatal adult (more )
Structure Level Pattern Image Note
TS28: caudate-putamen Strong
TS28: main olfactory bulb mitral cell layer Strong
TS28: medulla oblongata Strong
TS28: pons Strong
TS28: thalamus Strong
TS28: main olfactory bulb glomerular layer Moderate
TS28: main olfactory bulb granule cell layer Moderate
TS28: cerebellum white matter Absent
TS28: corpus callosum Absent
Specimen Not Shown: postnatal day 8 (more )
Structure Level Pattern Image Note
TS28: cerebellum external granule cell layer Strong
TS28: cerebellum internal granule cell layer Strong
TS28: cerebellum Purkinje cell layer Weak
Specimen 2B: postnatal adult (more )
Structure Level Pattern Image Note
TS28: spinal cord gray matter Strong 2B
TS28: spinal cord white matter Absent 2B
Specimen 3C: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: cardinal vein Present 3C
TS17: dorsal aorta Present 3C
TS17: heart Present 3C
Specimen 3J: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: basilar artery Present 3J
TS22: dorsal aorta Present 3J
TS22: hemiazygos vein Present 3J
TS22: internal carotid artery Present 3J
TS22: superior vena cava Present 3J
TS22: umbilical artery Present 3J
TS22: umbilical vein Present 3J
TS22: vertebral artery Present 3J
Specimen Not Shown: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: aorta Absent
TS27: vein Absent
Specimen 4B: postnatal day 8 (more )
Structure Level Pattern Image Note
TS28: central nervous system vascular element Present Regionally restricted 4B Expression is in meningeal vessels.
Specimen 5AA: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: arteriole Present Regionally restricted 5AA Expression is in meningeal vessels.
Specimen 5CC: postnatal day 8 (more )
Structure Level Pattern Image Note
TS28: arteriole Present Regionally restricted 5CC Expression is in meningeal vessels.
Specimen 5EE: postnatal day 19 (more )
Structure Level Pattern Image Note
TS28: arteriole Absent 5EE Expression is absent in meningeal vessels.
Specimen 5GG: postnatal adult (more )
Structure Level Pattern Image Note
TS28: arteriole Absent 5GG Expression is absent in meningeal vessels.
Specimen 6BB: postnatal day 8 (more )
Structure Level Pattern Image Note
TS28: brain blood vessel Present Regionally restricted 6BB Expression is in cerebral cortex vessels in regions with a lower neuronal cell density.
Specimen 7A: postnatal day 8 (more )
Structure Level Pattern Image Note
TS28: brain blood vessel Present Regionally restricted 7A Expression is in cerebral cortex vessels.
Specimen 7C: postnatal day 19 (more )
Structure Level Pattern Image Note
TS28: brain blood vessel Absent 7C Absent in cerebral cortex vessels.
Specimen 7E: postnatal adult (more )
Structure Level Pattern Image Note
TS28: brain blood vessel Absent 7E Absent in cerebral cortex vessels.
Specimen 8E: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: adrenal gland Strong 8E
TS22: liver Strong 8E
TS22: lung Strong 8E
TS22: metanephros Strong 8E
TS22: thymus primordium Strong 8E
TS22: intestine Present 8E
TS22: pancreas Present 8E
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory