Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Adam1btm1Tba
Name:	a disintegrin and metallopeptidase domain 1b; targeted mutation 1, Tadashi Baba
MGI ID:	MGI:3628759
Synonyms:	Adam1b-
Gene:	Adam1b  Location: Chr5:121638161-121641498 bp, - strand  Genetic Position: Chr5, 61.83 cM
Alliance:	Adam1btm1Tba page

Germline Transmission:	Earliest citation of germline transmission: J:109221
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A vector was designed to replace the 455-residue protein-coding region containing the pro-metalloprotease, disintegrin, and cysteine-rich domains at positions 79-533 with a neomycin resistance gene. Absense of transcript was confirmed in Northern blot of mutant testis. Also, protein extracts from testicular germ cells lacked a 120-kDa protein corresponding to the precursor form of Adam1b protein. (J:109221)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adam1b Mutation:	25 strains or lines available

Original:	J:109221 Kim E, et al., Mouse sperm lacking ADAM1b/ADAM2 fertilin can fuse with the egg plasma membrane and effect fertilization. J Biol Chem. 2006 Mar 3;281(9):5634-9
All:	1 reference(s)