Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Adam11tm1Sag
Name:	a disintegrin and metallopeptidase domain 11; targeted mutation 1, Koji Sagane
MGI ID:	MGI:3625523
Gene:	Adam11  Location: Chr11:102652265-102671088 bp, + strand  Genetic Position: Chr11, 66.48 cM
Alliance:	Adam11tm1Sag page

Germline Transmission:	Earliest citation of germline transmission: J:107127
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to replace exon 6 and part of exons 5 and 7 with a neomycin resistance gene. A termination was introduced into exon 5 in the pro-protein domain as a result, and any protein synthesized from this allele would be truncated and non-functional. Absence of protein in mutant cerebellum was confirmed by Western blot analysis. (J:107127)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adam11 Mutation:	37 strains or lines available

Original:	J:107127 Takahashi E, et al., Deficits in spatial learning and motor coordination in ADAM11-deficient mice. BMC Neurosci. 2006;7:19
All:	2 reference(s)