Apoetm1Yhg
Targeted Allele Detail
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Symbol: |
Apoetm1Yhg |
Name: |
apolipoprotein E; targeted mutation 1, Yadong Huang |
MGI ID: |
MGI:3624820 |
Synonyms: |
EGFPapoE |
Gene: |
Apoe Location: Chr7:19430034-19433113 bp, - strand Genetic Position: Chr7, 9.94 cM
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Alliance: |
Apoetm1Yhg page
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Germline Transmission: |
Earliest citation of germline transmission:
J:108323
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutation: |
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Insertion
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Mutation details: Coding sequence for EGFP with a stop codon was inserted into the locus immediately after the translation initiation codon in exon 2. A floxed neo was inserted into intron 3. Northern blot showed that the average level of mutant transcript in heterozygotes was 58% of that in wild-type mice.
(J:108323)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Apoe Mutation: |
145 strains or lines available
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Original: |
J:108323 Xu Q, et al., Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus. J Neurosci. 2006 May 10;26(19):4985-94 |
All: |
2 reference(s) |
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