Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Yy1tm2.1Yshi Name: YY1 transcription factor; targeted mutation 2.1, Yang Shi MGI ID: MGI:3624790 Synonyms: yy1f Gene: Yy1  Location: Chr12:108758899-108786074 bp, + strand  Genetic Position: Chr12, 59.58 cM Alliance: Yy1tm2.1Yshi page

Skin and hair pigmentation phenotype of Yy1tm2.1Yshi/Yy1tm2.1Yshi Tg(Tyr-cre)1Lru/Y mice Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:108369
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Exon 1 and the promoter region were flanked with loxP sites by homologous recombination. The FRT-flanked neomycin cassette inserted downstream of the 3' loxP site was removed by Flp mediated recombination. Protein expression is similar to wild-type. (J:108369)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	76 assay results 5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	20 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Yy1 Mutation:	34 strains or lines available

Original:	J:108369 Affar el B, et al., Essential dosage-dependent functions of the transcription factor yin yang 1 in late embryonic development and cell cycle progression. Mol Cell Biol. 2006 May;26(9):3565-81
All:	43 reference(s)