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Tg(MMTV-IGF2)Ml1Rkho
Transgene Detail
Summary
Symbol: Tg(MMTV-IGF2)Ml1Rkho
Name: transgene insertion Ml1, Rama Khokha
MGI ID: MGI:3527957
Synonyms: MMTV-IGF-II, Tg-Ml1
Transgene: Tg(MMTV-IGF2)Ml1Rkho  Location: unknown  
Alliance: Tg(MMTV-IGF2)Ml1Rkho page
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsA full length human IGF2 cDNA was cloned downstream of the MMTV LTR and an enhancer element from the untranslated region of the Ha-ras gene. The polyA sequence was derived from SV40. (J:95899)
Tumor Data
List all tumor models in MMHCdb carrying Tg(MMTV-IGF2)Ml1Rkho
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Other founder lines, Ml2 and Ml16, were also established.
References
Original:  J:95899 Moorehead RA, et al., Inhibition of mammary epithelial apoptosis and sustained phosphorylation of Akt/PKB in MMTV-IGF-II transgenic mice. Cell Death Differ. 2001 Jan;8(1):16-29
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory