Tg(UBC-CGB)1Hht
Transgene Detail
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| Symbol: |
Tg(UBC-CGB)1Hht |
| Name: |
transgene insertion 1, Ilpo Huhtaniemi |
| MGI ID: |
MGI:2445958 |
| Synonyms: |
hCGbeta TG |
| Transgene: |
Tg(UBC-CGB)1Hht Location: unknown
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| Alliance: |
Tg(UBC-CGB)1Hht page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Mutation details: The transgene consists of a human UBC promoter (including exon 1 and intron 1), a 579 bp human CGB cDNA fragment, and a bovine growth hormone polyadenylation signal. Transgene expression was confirmed by RT-PCR and immunohistochemical analysis in several tissues, including the ovary, pituitary gland, liver, kidney, uterus, and testis. Serum of transgenic female animals showeda 40-fold increase in enzyme activity compare to wild-type females.
(J:79060)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:79060 Rulli SB, et al., Reproductive disturbances, pituitary lactotrope adenomas, and mammary gland tumors in transgenic female mice producing high levels of human chorionic gonadotropin. Endocrinology. 2002 Oct;143(10):4084-95 |
| All: |
10 reference(s) |
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Analysis Tools
