Tg(Prl-TGFA)1Jek
Transgene Detail
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| Symbol: |
Tg(Prl-TGFA)1Jek |
| Name: |
transgene insertion 1, Jeffrey E Kudlow |
| MGI ID: |
MGI:2447436 |
| Transgene: |
Tg(Prl-TGFA)1Jek Location: unknown
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| Alliance: |
Tg(Prl-TGFA)1Jek page
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| Strain of Origin: |
C57BL/6 x SJL
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Prl-TGFA)1Jek expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
TGFA (7039) |
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Mutation details: A 900 kb human TGFA cDNA directed by a rat Prl promoter was used for the transgene. A 3 kb rat Prl promoter was used to drive transgene expression in in the pituitary lactotroph cells. Transgene expression was confirmed by Northern blot and immunofluorescence analysis of pituitary glands from transgenic animals.
(J:80651)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Two transgenic founder lines designated 8-8 and 13-8 express transgene RNA strictly in the pituitary. Only female animals express the transgene.
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| Original: |
J:80651 McAndrew J, et al., Targeting of transforming growth factor-alpha expression to pituitary lactotrophs in transgenic mice results in selective lactotroph proliferation and adenomas. Endocrinology. 1995 Oct;136(10):4479-88 |
| All: |
2 reference(s) |
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Analysis Tools
