Tg(LPV-TAg121*E107K)1Tvd
Transgene Detail
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| Symbol: |
Tg(LPV-TAg121*E107K)1Tvd |
| Name: |
transgene insertion 1, Terry Van Dyke |
| MGI ID: |
MGI:2445940 |
| Synonyms: |
LST1137K1, Tg(LPV-SV40T-C4500T)1Tvd |
| Transgene: |
Tg(LPV-TAg121*E107K)1Tvd Location: unknown
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| Alliance: |
Tg(LPV-TAg121*E107K)1Tvd page
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| Strain of Origin: |
(C57BL/6J X DBA/2)F2
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Mutation details: The transgene consists of a lymphotrophic papovavirus (LPV) enhancer/early promoter and a mutant SV40 T antigen sequence truncated after amino acid 121 followed by 11 missense residues and carrying a C4500T point mutation. The resulting protein lacks theSV40 small t antigen and Trp53-binding region and contains a glutamic acid to lysine subsitution at position 107 in the Rb1-binding domain. Regulatory sequences direct expression of the transgene in B- and T-lymphocytes and choroid plexus epithelium.
(J:72121)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:72121 Saenz Robles MT, et al., Induction versus progression of brain tumor development: differential functions for the pRB- and p53-targeting domains of simian virus 40 T antigen. Mol Cell Biol. 1994 Apr;14(4):2686-98 |
| All: |
2 reference(s) |
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Analysis Tools
