Tg(INSR)2Ebna
Transgene Detail
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| Symbol: |
Tg(INSR)2Ebna |
| Name: |
transgene insertion 2, Yousuke Ebna |
| MGI ID: |
MGI:2446614 |
| Synonyms: |
hIRK1030M(+), InsrK1030M |
| Transgene: |
Tg(INSR)2Ebna Location: unknown
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| Alliance: |
Tg(INSR)2Ebna page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(INSR)2Ebna expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
INSR (3643) |
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Mutation details: A transgenic construct was engineered to contain human insulin receptor sequence modified to contain a lysine to methionine missense mutation at codon 1030. The substitution of lysine 1030 with methionine is expected to disrupt the putative ATP binding site, thereby eliminating the tyrosine kinase activity of the protein. A 1.5 kb region of the human insulin receptor (INSR) promoter was included to direct expression in a variety of tissues. The expression of the human transcript in transgenic mice was verified by Northern blot analysis.
(J:80642)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Founder mice contained 2 to 3 copies of the transgenic construct.
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| Original: |
J:80642 Nishiyama T, et al., Expression of the gene encoding the tyrosine kinase-deficient human insulin receptor in transgenic mice. Gene. 1994 Apr 20;141(2):187-92 |
| All: |
3 reference(s) |
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Analysis Tools
