Tg(Col2a1)1Vuo
Transgene Detail
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| Symbol: |
Tg(Col2a1)1Vuo |
| Name: |
transgene insertion 1, Eero Vuorio |
| MGI ID: |
MGI:2449070 |
| Synonyms: |
Del1 |
| Transgene: |
Tg(Col2a1)1Vuo Location: unknown
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| Alliance: |
Tg(Col2a1)1Vuo page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Col2a1)1Vuo expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Col2a1 (MGI:88452) |
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Tg(Col2a1)1Vuo expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Col2a1 (MGI:88452) |
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Mutation details: A mouse Col2a1 gene deleted for a 150 bp region containing exon 7 and intron 7 was used for the transgene. 3 kb of mouse Col2a1 promoter sequences were used to drive transgene expression in chondrocytes. The transgene is expressed predominantly in the cartilage and eye as determined by RT-PCR analysis of transgenic tissues.
(J:1279)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Founder Del1 carries 6 integrated copies of the transgene. Founder Del1 and its heterozygous F1 offspring all exhibit smaller size compared to wild-type, but when bred to homozygosity the offspring exhibit severe short-limbed dwarfism.
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| Original: |
J:1279 Metsaranta M, et al., Chondrodysplasia in transgenic mice harboring a 15-amino acid deletion in the triple helical domain of pro alpha 1(II) collagen chain. J Cell Biol. 1992 Jul;118(1):203-12 |
| All: |
12 reference(s) |
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Analysis Tools
