Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sfrp1tm1Aksh
Name:	secreted frizzled-related protein 1; targeted mutation 1, Akihiko Shimono
MGI ID:	MGI:3621116
Synonyms:	Sfrp1-
Gene:	Sfrp1  Location: Chr8:23901518-23939648 bp, + strand  Genetic Position: Chr8, 11.48 cM
Alliance:	Sfrp1tm1Aksh page

Germline Transmission:	Earliest citation of germline transmission: J:106551
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An IRES-T-lacZ-bpA cassette replaced the first exon, which encodes the functional domain of the protein. Beta-gal staining confirmed that expression reflected endogenous protein expression. Transcript was not detected in mutants. (J:106551)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

3 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sfrp1 Mutation:	17 strains or lines available

Original:	J:106551 Satoh W, et al., Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis. Development. 2006 Mar;133(6):989-99
All:	24 reference(s)