Tg(Bmi1)33Mvl
Transgene Detail
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| Symbol: |
Tg(Bmi1)33Mvl |
| Name: |
transgene insertion 33, Maarten van Lohuizen |
| MGI ID: |
MGI:2178135 |
| Synonyms: |
Emu-bmi-33 |
| Transgene: |
Tg(Bmi1)33Mvl Location: unknown
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| Alliance: |
Tg(Bmi1)33Mvl page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Bmi1)33Mvl expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Bmi1 (MGI:88174) |
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Mutation details: Insertion of a transgene consisting of a Bmi1 gene linked to a Pim1 promoter, the immunoglobulin enhancer, and a Moloney murine leukemia virus LTR causes overexpression of BMI1 in thymus, bone marrow, and spleen. The promoter and enhancer module gives high levels of transgene expression in lymphoid cells and is active early in development. Northern blot analysis detected a highly abundant transgenic transcript of 3kb in 11.5 dpc transgenic embryos. In situ RNA hybridization studies show that BMI1 is ubiquitously overexpressed in 12.5 dpc transgenic embryos.
(J:24505)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:24505 Alkema MJ, et al., Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice. Nature. 1995 Apr 20;374(6524):724-7 |
| All: |
4 reference(s) |
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Analysis Tools
