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Tg(MMTV-HPV16E6E7)181Gnk
Transgene Detail
Summary
Symbol: Tg(MMTV-HPV16E6E7)181Gnk
Name: transgene insertion 181, Gen Kondoh
MGI ID: MGI:3521863
Synonyms: 181 transgenic line, E6E7, HPV16 E6E7, HPV16 E6-E7, line 181, MMTV-LTR-HPV16E6E7
Transgene: Tg(MMTV-HPV16E6E7)181Gnk  Location: unknown  
Alliance: Tg(MMTV-HPV16E6E7)181Gnk page
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThis transgene contains the MMTV LTR (mouse mammary tumor virus long terminal repeat) fused to the HPV16 E6 and E7 orf sequences. The polyA tail is from SV40. Mice possessed 4-5 head to tail copies of the transgene. The transgene followed a Mendelian pattern of inheritance. Transgene expression was detected in testicular tumors and the submandibular gland, but not in the lung or the spleen. (J:93826)
Tumor Data
List all tumor models in MMHCdb carrying Tg(MMTV-HPV16E6E7)181Gnk
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:93826 Kondoh G, et al., Very high incidence of germ cell tumorigenesis (seminomagenesis) in human papillomavirus type 16 transgenic mice. J Virol. 1991 Jun;65(6):3335-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory