Tg(Alb1-Trp53*R246S)24Sell
Transgene Detail
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| Symbol: |
Tg(Alb1-Trp53*R246S)24Sell |
| Name: |
transgene insertion 24, Stewart Sell |
| MGI ID: |
MGI:3529975 |
| Synonyms: |
lineage 24, p53ser246, Trp53R246S |
| Transgene: |
Tg(Alb1-Trp53*R246S)24Sell Location: unknown
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| Alliance: |
Tg(Alb1-Trp53*R246S)24Sell page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Alb1-Trp53*R246S)24Sell expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Trp53 (MGI:98834) |
Transgene codes for a protein with a arginine to serine mutation. |
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Mutation details: A 2.3 kb fragment containing the mouse Alb promoter/enhancer elements was cloned upstream of a mouse Trp53 minigene containing an Arg to Ser substitution at codon 246 (corresponding to human codon 249). This transgene was not linked with the wildtype Trp53 allele, and was incorporated in a chromosome other than the one carrying endogenous Trp53. Transgene incorporation was confirmed by Southern blot, and expression was confirmed by RT-PCR.
(J:47088)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:47088 Ghebranious N, et al., The mouse equivalent of the human p53ser249 mutation p53ser246 enhances aflatoxin hepatocarcinogenesis in hepatitis B surface antigen transgenic and p53 heterozygous null mice. Hepatology. 1998 Apr;27(4):967-73 |
| All: |
3 reference(s) |
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Analysis Tools
