Tg(Cp-EGFP)25Gaia Transgene Detail MGI Mouse (MGI:3620129)

Tg(Cp-EGFP)25Gaia
Transgene Detail

Summary

Symbol:	Tg(Cp-EGFP)25Gaia
Name:	transgene insertion 25, Nicholas R Gaiano
MGI ID:	MGI:3620129
Synonyms:	TNR, transgenic Notch reporter
Transgene:	Tg(Cp-EGFP)25Gaia Location: unknown
Alliance:	Tg(Cp-EGFP)25Gaia page

Transgene
origin

Strain of Origin:

(C57BL/6J x SJL/J)F2

Transgene
description

Transgene Type:		Transgenic (Reporter)
Mutation:		Insertion
		Mutation details: The transgene comprises four tandem copies of the C-promoter binding factor 1 (CBF1/RBPSUH) binding site of the Epstein-Barr virus major latency C promoter (Cp), followed by the SV40 minimal promoter and the coding sequence for enhanced green fluorescent protein. Cells of mice bearing this transgene express green fluorescent protein when the Notch signaling pathway is activated. (J:96367)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

EGFP is expressed from this transgene when the promoter is activated by binding to the upstream CBF1 binding elements of a complex comprising CBF1, the transcriptional coactivator mastermind like 1 (Drosophila)(MML1), and the intracellular cleavage product resulting from interaction of the transmembrane Notch receptor with ligand.

References

Original:	J:96367 Duncan AW, et al., Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol. 2005 Mar;6(3):314-22
All:	45 reference(s)

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