Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Urostm2Cged
Name:	uroporphyrinogen III synthase; targeted mutation 1, Cecile Ged
MGI ID:	MGI:3620007
Synonyms:	Urosdel
Gene:	Uros  Location: Chr7:133287972-133311801 bp, - strand  Genetic Position: Chr7, 77.26 cM
Alliance:	Urostm2Cged page

Germline Transmission:	Earliest citation of germline transmission: J:107043
Parent Cell Line:	H1 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance gene was inserted into the locus, replacing part of the coding sequence. The resulting transcript encodes a truncated protein of 204 amino acids instead of 265. (J:107043)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Uros Mutation:	18 strains or lines available

Original:	J:107043 Bensidhoum M, et al., The disruption of mouse uroporphyrinogen III synthase (uros) gene is fully lethal. Transgenics. 1998;2:275-280
All:	2 reference(s)