Tg(KRT14-HPV16E6)5737Plam
Transgene Detail
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| Symbol: |
Tg(KRT14-HPV16E6)5737Plam |
| Name: |
transgene insertion 5737, Paul F Lambert |
| MGI ID: |
MGI:3521744 |
| Synonyms: |
5737, K14-E6, K14E6, K14E6 5737, K14E6WT |
| Transgene: |
Tg(KRT14-HPV16E6)5737Plam Location: unknown
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| Alliance: |
Tg(KRT14-HPV16E6)5737Plam page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Mutation details: A human papilloma virus 16 (HPV16) genomic fragment (nt79-883) encompassing both the E6 and E7 genes was cloned between the human KRT14 promoter and polyA sequences. Only E6 is expressed due to the presence of a translation termination linker in the N-terminal region of the E7 gene. This line was estimated by Southern blot analysis to carry approximately 15 copies of the transgene. In situ hybridization demonstrates expession of E6 mRNA in the epidermis and also in the dermis, but confined largely to hair follicles in the latter.
(J:55965)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 2 strains available
Cell Lines: 0 lines available
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| Original: |
J:55965 Song S, et al., The human papillomavirus type 16 E6 gene alone is sufficient to induce carcinomas in transgenic animals. J Virol. 1999 Jul;73(7):5887-93 |
| All: |
25 reference(s) |
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Analysis Tools
