Tg(TcraCl1,TcrbCl1)1Shrm Transgene Detail MGI Mouse (MGI:3617607)

Tg(TcraCl1,TcrbCl1)1Shrm
Transgene Detail

Summary

Symbol:	Tg(TcraCl1,TcrbCl1)1Shrm
Name:	transgene insertion 1, Linda Sherman
MGI ID:	MGI:3617607
Synonyms:	Clone-1 TCR
Transgene:	Tg(TcraCl1,TcrbCl1)1Shrm Location: unknown
Alliance:	Tg(TcraCl1,TcrbCl1)1Shrm page

Transgene
origin

Strain of Origin:

B10.D2-Hc¹ H2^d H2-T18^c/nSnJ

Transgene
description

Transgene Type:

Transgenic (Inserted expressed sequence)

Mutation:

Insertion

Tg(TcraCl1,TcrbCl1)1Shrm expresses 2 genes

Mutation details: The transgene encodes a low avidity T cell receptor (TCR) that recognizes the influenza virus hemagglutinin (HA) epitope HA518-526 in the context of the H2-K^d MHC class I molecule. The rearranged Tcra and Tcrb genes, which have joined Valpha1/Jalpha11 and Vbeta8.2/D/Jbeta2.4, respectively, were amplified from cytotoxic T lymphocyte (CTL) clone 1. Clone 1 was derived from a transgenic B10.D2 mouse that expressed influenza virus HA as a self-antigen in pancreatic beta cells, which resulted in production of lower-avidity TCRs than those made by wild-type B10.D2 mice after infection with influenza virus strain A/PR/8/32. (J:97745)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

CD8⁺ T cells bearing this transgene, when transferred to mice that develop pancreatic tumors expressing influenza virus HA, can be induced to exhibit both effector function and antitumor activity only if HA-responsive CD4⁺ T cells are co-transferred and the mice are subsequently infected with influenza virus. : J:97745

References

Original:	J:97745 Lyman MA, et al., The fate of low affinity tumor-specific CD8+ T cells in tumor-bearing mice. J Immunol. 2005 Mar 1;174(5):2563-72
All:	4 reference(s)

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