Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Tg(Atoh1-cre/Esr1*)14Fsh
Name:	transgene insertion 14, Gordon Fishell
MGI ID:	MGI:3615691
Synonyms:	Atoh1-cre, Math1-cre, Math1-CreERT2, Tg(Atoh1-cre/ESR1)1Fsh, Tg(HBB-cre)1Fsh
Transgene:	Tg(Atoh1-cre/Esr1*)14Fsh  Location: unknown
Alliance:	Tg(Atoh1-cre/Esr1*)14Fsh page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(Atoh1-cre/Esr1*)14Fsh expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Atoh1 (MGI:104654)   Mutation details: The transgene was designed with a 1.4 kb mouse Math1 (Atoh1) 3' enhancer (and a beta-globin minimal promoter) sequence upstream of a CreERT2 fusion gene (Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain). Tamoxifen-inducible cre activity is observed in neural progenitors of the cerebellar rhombic lip, dorsal hindbrain and spinal cord, as well as in inner-ear primordia (with a limited amount of ectopic expression in the primordium of the hippocampus but not the cortex). (J:105186)

Activity:	Tissue activity of this recombinase allele
Driver:	Atoh1 (mouse) Summary of all recombinase alleles driven by Atoh1. Comparative matrix view of recombinase activities Alliance mouse Atoh1 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

2 assay results

List all tumor models in MMHCdb carrying Tg(Atoh1-cre/Esr1*)14Fsh

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:105186 Machold R, et al., Math1 is expressed in temporally discrete pools of cerebellar rhombic-lip neural progenitors. Neuron. 2005 Oct 6;48(1):17-24
All:	67 reference(s)