Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Aqp8tm1Ask
Name:	aquaporin 8; targeted mutation 1, Alan S Verkman
MGI ID:	MGI:3613030
Synonyms:	Aqp8-, AQP8-
Gene:	Aqp8  Location: Chr7:123061517-123067226 bp, + strand  Genetic Position: Chr7, 67.42 cM, cytoband F3
Alliance:	Aqp8tm1Ask page

Germline Transmission:	Earliest citation of germline transmission: J:104681
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 4-6 were replaced with a neomycin cassette. Northern blot failed to detect transcript and Western blot confirmed the absence of protein in mutant submandibular gland, liver, colon and testes. (J:104681)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aqp8 Mutation:	14 strains or lines available

Original:	J:104681 Yang B, et al., Phenotype analysis of aquaporin-8 null mice. Am J Physiol Cell Physiol. 2005 May;288(5):C1161-70
All:	7 reference(s)