Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(TcraBDC2.5,TcrbBDC2.5)1Doi
Name:	transgene insertion 1, Christophe Benoist
MGI ID:	MGI:2181203
Synonyms:	BDC2.5, BDC-2.5/N TCR Tg, Tg(TcraBDC2.5)2Doi, Tg(TcrbBDC2.5)2Doi
Transgene:	Tg(TcraBDC2.5,TcrbBDC2.5)1Doi  Location: unknown
Alliance:	Tg(TcraBDC2.5,TcrbBDC2.5)1Doi page

Strain of Origin:

(C57BL/6 x SJL)F2

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(TcraBDC2.5,TcrbBDC2.5)1Doi expresses 2 genes Transgene expresses: Organism Expressed Gene Note mouse Tcra (MGI:98553) mouse Tcrb (MGI:98578)   Mutation details: This transgene results from the coinjection of two constructs derived from diabetogenic T-cell clone BDC2.5. The Tcra construct contains a rearranged Tcra sequence (V alpha J alpha) that begins 20 bp 5' of the ATG site and ends 30 bp 3' of the splice donor sequence of J alpha 17. The 6.5 Tcrb construct contains rearranged Tcrb sequence (V beta D beta J beta) flanked by 2 kb of 5' regulatory sequences and 3.5 kb of 3' DNA containing the unrearranged J beta 1.3 to J beta 1.6 sequences, and precedes a 12 kb sequence containing the C beta 2 region. (J:77007)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available

Original:	J:77007 Katz JD, et al., Following a diabetogenic T cell from genesis through pathogenesis. Cell. 1993 Sep 24;74(6):1089-100
All:	147 reference(s)