Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Car14tm1Sly
Name:	carbonic anhydrase 14; targeted mutation 1, William S Sly
MGI ID:	MGI:3611771
Synonyms:	CAXIVdl1Sws, CA XIV KO
Gene:	Car14  Location: Chr3:95805080-95812003 bp, - strand  Genetic Position: Chr3, 41.48 cM
Alliance:	Car14tm1Sly page

Germline Transmission:	Earliest citation of germline transmission: J:103742
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ KitlSl-J/J

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was used to replace exon 4, 16 bp of intron 3, and 13 bp of intron 4 with the self-excising tACE-CRE-neo cassette. The frameshift resulting from recombination putatively results in early termination in exon 5. RT-PCR failed to detect the predicted 0.75 fragment in brain, heart, kidney, liver or muscle samples. Protein was not detected in Western blot analysis of the same tissues. (J:103742)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Car14 Mutation:	18 strains or lines available

Original:	J:103742 Shah GN, et al., Carbonic anhydrase IV and XIV knockout mice: roles of the respective carbonic anhydrases in buffering the extracellular space in brain. Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16771-6
All:	8 reference(s)