Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Slc8a1tm2Kdp
Name:	solute carrier family 8 (sodium/calcium exchanger), member 1; targeted mutation 2, Kenneth D Philipson
MGI ID:	MGI:3609617
Synonyms:	NCX-
Gene:	Slc8a1  Location: Chr17:81680534-82045806 bp, - strand  Genetic Position: Chr17, 51.29 cM
Alliance:	Slc8a1tm2Kdp page

Germline Transmission:	Earliest citation of germline transmission: J:103484
Parent Cell Line:	LW1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exon 2, containing 64% of the coding sequence including the transcriptional start site, was deleted via cre mediated recombination. Immunoblot failed to detect protein in mutant embryo hearts. (J:103484)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc8a1 Mutation:	55 strains or lines available

Original:	J:103484 Reuter H, et al., The Na+-Ca2+ exchanger is essential for the action of cardiac glycosides. Circ Res. 2002 Feb 22;90(3):305-8
All:	4 reference(s)