Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Prox1tm2Gco
Name:	prospero homeobox 1; targeted mutation 2, Guillermo Oliver
MGI ID:	MGI:3609548
Synonyms:	Prox1flox, Prox1loxP
Gene:	Prox1  Location: Chr1:189850232-189902911 bp, - strand  Genetic Position: Chr1, 95.85 cM
Alliance:	Prox1tm2Gco page

Germline Transmission:	Earliest citation of germline transmission: J:102652
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A targeting construct was created to flank exons 2 and 3, sequence encoding the homeodomain and Prox domain, with loxP sites. Loss of this sequence would render the locus transcriptionally inactive. (J:102652)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prox1 Mutation:	43 strains or lines available

Original:	J:102652 Harvey NL, et al., Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity. Nat Genet. 2005 Oct;37(10):1072-81
All:	29 reference(s)