Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Prkcetm1Bsca
Name:	protein kinase C, epsilon; targeted mutation 1, Lisardo Bosca
MGI ID:	MGI:3609215
Synonyms:	PKCepsilon-
Gene:	Prkce  Location: Chr17:86475213-86965347 bp, + strand  Genetic Position: Chr17, 56.74 cM
Alliance:	Prkcetm1Bsca page

Germline Transmission:	Earliest citation of germline transmission: J:103337
Parent Cell Line:	GK129 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A targeting vector was designed to insert stop codons in all three reading frames, an IRES-lacZ-pA and a neomycin resistance gene into exon 1. Northern and Western blot analyses confirmed that transcript and protein were absent in mutants. (J:103337)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prkce Mutation:	39 strains or lines available

Original:	J:103337 Castrillo A, et al., Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection. J Exp Med. 2001 Nov 5;194(9):1231-42
All:	6 reference(s)