Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Yap1tm1Smil
Name:	yes-associated protein 1; targeted mutation 1, Sharon L Milgram
MGI ID:	MGI:3608880
Synonyms:	Yaptm1Smil
Gene:	Yap1  Location: Chr9:7932000-8004597 bp, - strand  Genetic Position: Chr9, 2.46 cM
Alliance:	Yap1tm1Smil page

Germline Transmission:	Earliest citation of germline transmission: J:102253
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The targeting event replaced approximately 1 kb of the gene, including the translation initiation site and all but 10 bp of exon 1, with a floxed MC1-neo cassette in reverse orientation. Western blot analysis of lysates of whole E8.5 embryos using affinity-purified antiserum to the C-terminus of human YAP protein produced no signal. (J:102253) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	11 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Yap1 Mutation:	37 strains or lines available

Original:	J:102253 Morin-Kensicki EM, et al., Defects in yolk sac vasculogenesis, chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of yap65. Mol Cell Biol. 2006 Jan;26(1):77-87
All:	6 reference(s)