Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	MkksGt(OST367255)Lex
Name:	McKusick-Kaufman syndrome; gene trap OST367255, Lexicon Genetics
MGI ID:	MGI:3608879
Synonyms:	Bbs6-, Mkks-, MkksGt(Betageo-BTK)705Lex
Gene:	Mkks  Location: Chr2:136715700-136733309 bp, - strand  Genetic Position: Chr2, 67.64 cM
Alliance:	MkksGt(OST367255)Lex page

Mutant Cell Line:	OST367255
Germline Transmission:	Earliest citation of germline transmission: J:102697
Parent Cell Line:	Lex-1 (ES Cell)
Strain of Origin:	129S5/SvEvBrd
Project Collection:	Lexicon

Allele Type:    Gene trapped (Null/knockout, Reporter) Mutation:    Insertion of gene trap vector   Mutation details: A gene trap vector consisting of LTR sites flanking a Beta-geo cassette containing a splice acceptor integrated into the intron between exon 1 and 2. RT-PCR confirmed absence of RNA. (J:102697) Sequence Tags:  Sequence tag details (1 tag) Tag ID GenBank ID Method Tag Location (trapped strand)* Select OST367255 CG638190 (MGI Seq Detail) 3' RACE Chr2:136723326-136727621 bp (-) * GRCm39 (strand of gene trap mutagenesis) Selected Tags: download BLAST at NCBI Genome Context:  Genome Browser view of this mutation 1 gene trap insertions have trapped this gene View all gene trap sequence tags in this region

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	23 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mkks Mutation:	27 strains or lines available

Original:	J:102697 Ross AJ, et al., Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. Nat Genet. 2005 Oct;37(10):1135-40
All:	7 reference(s)