Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Gria1tm3Rlh
Name:	glutamate receptor, ionotropic, AMPA1 (alpha 1); targeted mutation 3, Richard Huganir
MGI ID:	MGI:3605221
Synonyms:	GluR1-
Gene:	Gria1  Location: Chr11:56902342-57221070 bp, + strand  Genetic Position: Chr11, 34.51 cM
Alliance:	Gria1tm3Rlh page

Germline Transmission:	Earliest citation of germline transmission: J:101578
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance gene replaced the exon encodeing transmembrane domains one and two. The presumably truncated protein was expressed weakly in mutants. (J:101578)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gria1 Mutation:	62 strains or lines available

Original:	J:101578 Kim CH, et al., Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1. Nat Neurosci. 2005 Aug;8(8):985-7
All:	7 reference(s)