Tg(Abpa-FSHR*D567G)1Cmal
Transgene Detail
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| Symbol: |
Tg(Abpa-FSHR*D567G)1Cmal |
| Name: |
transgene insertion 1, Charles M Allan |
| MGI ID: |
MGI:2446530 |
| Synonyms: |
Tg-FSHR+, TgFSHR*D567G |
| Transgene: |
Tg(Abpa-FSHR*D567G)1Cmal Location: unknown
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| Alliance: |
Tg(Abpa-FSHR*D567G)1Cmal page
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| Strain of Origin: |
(C3H/HeH x 101/H)F1
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Abpa-FSHR*D567G)1Cmal expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
FSHR (2492) |
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Transgene codes for a protein with an aspartic acid to glycine mutation. |
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Mutation details: The transgene consists of a rat Abpa promoter and a human FSHR minigene. The FSHR minigene contains exon 1, a shortened intron 1 lacking the midregion, and exons 2-10 with no intervening introns. The minigene also includes a mutation causing an aspartic acid to glycine change at amino acid residue 567. The rat Abpa promoter directs transgene expression in Sertoli cells. Transgene expression was confirmed by RT-PCR analysis of testes and ovary total RNA; expression was also detected in the brain and, at lower levels, in the pituitary.
(J:79967)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Fertilized oocytes derived from (C3H/HeH x 101/H)F1 animals carrying the Gnrh1hpg mutation were used for transgene injection. Two transgenic founder lines, RR3 and RR4, were established and used for analysis.
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| Original: |
J:79967 Haywood M, et al., An activated human follicle-stimulating hormone (FSH) receptor stimulates FSH-like activity in gonadotropin-deficient transgenic mice. Mol Endocrinol. 2002 Nov;16(11):2582-91 |
| All: |
4 reference(s) |
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Analysis Tools
