Tg(Thy1-PPP2CA*L199P)19Gotz
Transgene Detail
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| Symbol: |
Tg(Thy1-PPP2CA*L199P)19Gotz |
| Name: |
transgene insertion 19, Jurgen Gotz |
| MGI ID: |
MGI:3604151 |
| Transgene: |
Tg(Thy1-PPP2CA*L199P)19Gotz Location: unknown
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| Alliance: |
Tg(Thy1-PPP2CA*L199P)19Gotz page
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| Transgene Type: |
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Transgenic (Dominant negative, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Mutation details: The dominant negative mutant form of the human protein phosphatase 2 catalytic subunit, alpha isoform, was expressed under the control of the neuron specific Thy1 promoter. High expression was shown in the cortical, hippocampal, and cerebellar neurons. Line 21 was also created.
(J:100966)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:100966 Kins S, et al., Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice. J Biol Chem. 2001 Oct 12;276(41):38193-200 |
| All: |
1 reference(s) |
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Analysis Tools
