Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Srftm1Rjs
Name:	serum response factor; targeted mutation 1, Robert J Schwartz
MGI ID:	MGI:3604097
Synonyms:	SRF-, SRFLacZ
Gene:	Srf  Location: Chr17:46859255-46867101 bp, - strand  Genetic Position: Chr17, 22.9 cM
Alliance:	Srftm1Rjs page

Germline Transmission:	Earliest citation of germline transmission: J:101471
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted Mutation:    Insertion   Mutation details: Sequence encoding the DNA binding and dimerization domains of the protein was replaced by the insertion of an NLS-betagalactosidase-neomycin cassette. In situ hybridization demonstrated expression in embryos ranging from E7.5 to E9.5 predominantly in the cardiac crescent and later in the heart tube, the somites, and the precondensed mesenchyme in the tail, consistent with the expression of the endogenous gene. (J:101471)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Srf Mutation:	25 strains or lines available

Original:	J:101471 Barron MR, et al., Serum response factor, an enriched cardiac mesoderm obligatory factor, is a downstream gene target for Tbx genes. J Biol Chem. 2005 Mar 25;280(12):11816-28
All:	4 reference(s)